Discover the Revolutionary Genes Behind Extraordinary Longevity
Have you ever wondered why some individuals or species live longer than others? Recent scientific discoveries have shed light on this fascinating topic, revealing that certain genes, known as longevity genes, play a crucial role in determining lifespan. These genes come in two types: pro-longevity genes that increase lifespan, and anti-longevity genes that do the opposite. In this article, we’ll explore these longevity genes, how they impact lifespan, and other factors that contribute to longevity.
Knowing About Genes for Longevity
Longevity genes are unique because their expression is directly linked to lifespan. For instance, if a pro-longevity gene is overexpressed, it can increase an individual’s lifespan, while underexpression of the same gene may shorten it. Conversely, anti-longevity genes work in the opposite way; their increased expression could lead to a shorter lifespan.
One key gene in human longevity is CISD2, located on a region of the human chromosome associated with lifespan variations. CISD2 is believed to play a critical role in maintaining mitochondrial function, which is essential for cell growth and division.
Examples of Longevity Genes
Scientists have identified various longevity genes across different species, including:
TDRP, MC2R, FBXO25, FBXL21: Associated with longevity in Cane Corso dogs.
FOXO3: Influences longevity in multiple species.
MAP3K5: A kinase signaling gene linked to lifespan.
Insulin/IGF1 Pathway Genes: Variants in this pathway are also connected to longevity.
Additionally, polymorphisms in genes like IGF1R, PON1, APOC3, and PI3K, and the extension in longevity through IIS, are noted in ageing studies.
Factors Affecting Lifespan
Apart from genetics, several other factors influence an animal’s lifespan:
Basal Metabolic Rate (BMR): Lower metabolic rates per unit mass or cell in larger animals may contribute to longer lifespans.
Body Mass and Temperature: Larger animals generally live longer due to reduced cellular damage.
Diet: Nutrition plays a significant role in lifespan.
Hibernation Ability: Animals capable of hibernation often have extended lifespans.
Genetic Variations in Humans
In humans, common genetic variations linked to long lifespans are found in the APOE, FOXO3, and CETP genes. However, these are not present in all individuals with exceptional longevity. It’s clear that while genetics plays a significant role, it’s not the sole determinant of lifespan.
Ageing and Reproduction
Interestingly, some genes that promote ageing are involved in reproduction, like those encoding yolk proteins. Additionally, the insulin-like INS-7 protein can influence ageing by interacting with the insulin/IGF-1 receptor, affecting lifespan regulation.
The study of longevity genes opens a new window into understanding how life spans are determined and potentially extended. While genetics plays a crucial role, it’s important to remember that lifestyle and environmental factors also significantly impact longevity. As research continues, we may uncover more secrets behind the complex interplay of genes and longevity, bringing us closer to unraveling the mysteries of a longer, healthier life.
References:
Furuyama T, Yamashita H, Kitayama K, Higami Y, Shimokawa I, Mori N. Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles. Microsc Res Tech. 2002;59:331–334. [PubMed] [Google Scholar]
Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell. 2007;128:309–323. [PMC free article] [PubMed] [Google Scholar]
Webb AE, Brunet A. FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci. 2014;39:159–169. [PMC free article] [PubMed] [Google Scholar]
Morris BJ. Seven sirtuins for seven deadly diseases of aging. Free Radic Biol Med. 2013;56:133–71. [PubMed] [Google Scholar]
Eijkelenboom A, Burgering BM. FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol. 2013;14:83–97. [PubMed] [Google Scholar]
Morris BJ. A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer. (Review) J Hypertens. 2005;23:1285–1309. [PubMed] [Google Scholar]
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