Plant-Based Medicines Without Plants: The Prospects for Drug Bioprinting

Printing Plant-Based Pharmaceuticals Without Plants: The Future of Drug Production

In an era where climate change, invasive pests, and diseases threaten the very existence of plant species, a groundbreaking innovation emerges from the labs of the University of Rochester. A group of ten undergraduate students, self-dubbed “Team RoSynth,” has pioneered an affordable 3D-bioprinting system that could revolutionize the way we produce plant-based drugs and pharmaceuticals.

The Innovation Behind Team RoSynth

The core of Team RoSynth’s innovation lies in their unique approach to 3D printing living organisms. By utilizing hydrogels, jelly-like substances, the team can house genetically modified bacteria and yeast within the same space without direct contact. This separation is crucial as it prevents the microbes from outcompeting each other while still allowing them to communicate and exchange molecules. This ingenious setup facilitates the synthetic creation of chemicals found in plants, bypassing the need for the plants themselves.

A Solution to a Growing Problem

The implications of Team RoSynth’s work are vast. With many plant species endangered or threatened by various environmental challenges, the demand for plant-derived drugs and pharmaceuticals has never been higher. Traditional farming practices struggle to keep up, making the need for alternative production methods urgent.

Enter the affordable 3D-printing system developed by the students. It optimizes the production of in-demand drugs, offering a sustainable solution to a pressing issue. According to Anne S. Meyer, an associate professor in the Department of Biology at the University of Rochester and one of the team’s advisors, the system represents a significant leap forward. By keeping the yeast and bacteria separate yet communicative within hydrogels, the team has found a way to rapidly and efficiently produce plant-based chemicals without the plants.

Real-World Applications

The potential applications of this technology are vast. From aspirin, traditionally derived from willow tree bark, to taxol, a cancer drug developed from yew trees, the method could ensure a steady and sustainable supply of vital medications. Moreover, it opens the door to producing pharmaceuticals from plants that are currently endangered, providing hope for the future of medicine.

The Future of Pharmaceutical Production

Team RoSynth’s work is a beacon of hope in the fight against the extinction of plant species and the challenges of drug production. Their affordable 3D-bioprinting system not only promises to safeguard the production of plant-based pharmaceuticals but also heralds a new era of sustainable drug manufacturing. As we face the realities of climate change and environmental degradation, innovations like this offer a path forward, ensuring that crucial medications remain available to those who need them most, all while protecting our planet’s precious biodiversity.

In conclusion, the work of Team RoSynth at the University of Rochester represents not just a significant scientific achievement but a vital step towards a more sustainable and secure future for pharmaceutical production. By harnessing the power of 3D bioprinting and the ingenuity of young scientists, we are witnessing the dawn of a new era in drug manufacturing, one that promises to protect both our health and our environment.

References:

Bácskay I., Ujhelyi Z., Fehér P., Arany P. The Evolution of the 3D-Printed Drug Delivery Systems: A Review. Pharmaceutics. 2022;14:1312. doi: 10.3390/pharmaceutics14071312. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

Rautamo M., Kvarnström K., Sivén M., Airaksinen M., Lahdenne P., Sandler N. Benefits and prerequisites associated with the adoption of oral 3D-printed medicines for pediatric patients: A focus group study among healthcare professionals. Pharmaceutics. 2020;12:229. doi: 10.3390/pharmaceutics12030229. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

Tan Y.J.N., Yong W.P., Kochhar J.S., Khanolkar J., Yao X., Sun Y., Ao C.K., Soh S. On-demand fully customizable drug tablets via 3D printing technology for personalized medicine. J. Control Release. 2020;322:42–52. doi: 10.1016/j.jconrel.2020.02.046. [PubMed] [CrossRef] [Google Scholar]

Pandey M., Choudhury H., Fern J.L.C., Kee A.T.K., Kou J., Jing J.L.J., Her H.C., Yong H.S., Ming H.C., Bhattamisra S.K. 3D printing for oral drug delivery: A new tool to customize drug delivery. Drug Deliv. Transl. Res. 2020;10:986–1001. doi: 10.1007/s13346-020-00737-0. [PubMed] [CrossRef] [Google Scholar]

Beer N., Kaae S., Genina N., Sporrong S.K., Alves T.L., Hoebert J., De Bruin M.L., Hegger I. Magistral Compounding with 3D Printing: A Promising Way to Achieve Personalized Medicine. Ther. Innov. Regul. Sci. 2023;57:26–36. doi: 10.1007/s43441-022-00436-7. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

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