Ectogenesis: Building a Bridge for Future Reproduction

Ectogenesis

Despite popular dystopian imaginings, complete ectogenesis remains a distant reality. Current research predominantly centers on partial ectogenesis, involving the growth of a fetus in a womb before transferring it to an artificial incubator. This groundbreaking concept has so far been explored mainly in animal models, prompting discussions at the U.S. Food and Drug Administration regarding its potential application in humans.

Complete Ectogenesis and Prospective Medical Benefits:

Looking ahead, the second part of this chapter focuses on complete ectogenesis. This process entails creating a fetus through in vitro fertilization (IVF) outside a woman’s body and then immediately transferring it into an artificial womb for the entire gestation period. This approach could revolutionize reproductive technology, eliminating the need for the mother’s body in the gestation process.

Medical Benefits: Ectogenesis presents potential medical advantages by offering a controlled environment for the development of high-risk or premature infants. This breakthrough may mitigate the risks associated with preterm birth, enhancing the chances of survival and promoting healthier outcomes for these infants.

Future Developments and Ethical Concerns:

The future of ectogenesis lies in the development of external wombs designed for embryos, contributing to the preservation of maternal health. However, ethical concerns loom large, encompassing issues such as human subjects’ research protections, the impact on parent-child relationships, potential societal risks to women, and the potential creation of a socioeconomic divide between the affluent and the less privileged.

The Beginning and In Vitro Fertilization (IVF):

In the realm of reproductive technologies, embryos for IVF are typically cultivated in laboratories for several days before implantation. Researchers have even extended this period to two weeks and anticipate further advancements in the near future.

Pioneering Studies and Animal Models:

In a groundbreaking study in 2017, researchers successfully kept eight lambs alive for up to four weeks using an artificial womb. During this time, the animals underwent significant development, showcasing the potential for organ maturity. Although the animals were euthanized for further study, these findings open new avenues for understanding the impact of ectogenesis on organ development.

Ectogenesis provides a window into a future in which reproduction knows no bounds, sitting at the nexus of scientific advancement and ethical issues. While scientists continue to work through the complexities of this field, society needs to consider the profound effects of ectogenesis on ethics, medicine, and the basic structure of human existence.

References:

Bird SD. Artificial placenta: analysis of recent progress. Eur J Obstet Gynecol Reprod Biol. 2017;208:61–70. Article Google Scholar

Hornick MA, Davey MG, Partridge EA, Mejaddam AY, McGovern PE, Olive AM, et al. Umbilical cannulation optimizes circuit flows in premature lambs supported by the EXTra-uterine Environment for Neonatal Development (EXTEND). J Physiol. 2018;596(9):1575–85. Article Google Scholar

Kading JC, Langley MW, Lautner G, Jeakle MMP, Toomasian JM, Fegan TL, et al. Tidal flow perfusion for the artificial placenta: a paradigm shift. ASAIO J. 2020;66:796–802. Article Google Scholar

Partridge EA, Davey MG, Hornick MA, McGovern PE, Mejaddam AY, Vrecenak JD, et al. An extra-uterine system to physiologically support the extreme premature lamb. Nat Commun. 2017;8:15112. Article Google Scholar

Usuda H, Watanabe S, Saito M, Sato S, Musk GC, Fee ME, et al. Successful use of an artificial placenta to support extremely preterm ovine fetuses at the border of viability. Am J Obstet Gynecol. 2019;221:69.e1-.e17.

Bonito V. Multimillion grant brings artificial womb one step closer. TU/e. https://www.tue.nl/en/news/news-overview/multimillion-grant-brings-artificial-womb-one-step-closer/. Accessed 2 October 2020.

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