Secrets of Alpha-Ketoglutarate (AKG): A Natural Anti-Aging Wonder

Discovering Alpha-Ketoglutarate (AKG): A Miracle Natural Anti-Aging Agent


AKG (alpha-ketoglutarate): An explanation

Alpha-ketoglutarate (AKG) is a crucial player in the body’s energy production process, influencing various physiological functions. Its roles include regulating the Krebs cycle, amino acid production, cellular signaling, maintaining stem cell health, bone and gut metabolism, and protecting stem cells against aging. AKG is an unsung hero that also improves mitochondrial health, maintains a healthy epigenome, and helps control the overall rate of the citric acid cycle.

Evidence of Anti-Aging Benefits:

Research indicates that AKG supplementation can lead to improvements in both lifespan and healthspan in various model animals. For instance, studies using the calcium salt of AKG (Ca-AKG) have demonstrated increased lifespan by reducing systemic inflammatory cytokines and inducing the anti-inflammatory cytokine IL-10. Chronic inflammation, a precursor to numerous age-related diseases, can be mitigated by AKG, offering potential health benefits.

Mechanism of Action:

Recent studies shed light on the mechanism behind AKG’s anti-aging effects. Female mice receiving AKG produced higher levels of a molecule that suppresses inflammation. This finding is crucial, as chronic inflammation is associated with diseases such as cancer, heart disease, arthritis, and dementia. The induction of IL-10 by dietary AKG is proposed to suppress chronic inflammation, contributing to a longer and healthier life.

Natural Sources of Alpha-Ketoglutarate (AKG):

While AKG can be obtained through supplementation, it is also naturally occurring in various foods. Both plant- and animal-based sources offer this organic acid, making it accessible for those seeking to incorporate it into their diet. Some examples of AKG-rich foods include meat and poultry, nuts and seeds (such as almonds, walnuts, and sunflower seeds), certain fermented foods, perennial ryegrass, and lemon leaves.

AKG’s Role in Cellular Metabolism:

AKG plays multiple roles in cellular metabolism, influencing amino acid concentration, inhibiting protein catabolism, enhancing protein synthesis, and controlling lipid levels. Its ability to be rapidly transaminated into various amino acids further highlights its importance in maintaining overall cellular health.

Alpha-ketoglutarate (AKG) emerges as a promising natural compound with anti-aging potential, offering a holistic approach to promoting longevity and healthspan. From regulating cellular metabolism to suppressing chronic inflammation, AKG’s diverse functions make it a key player in the quest for a healthier and more youthful life. Whether through dietary sources or supplementation, incorporating AKG into one’s routine may unlock the secrets to a longer, healthier, and more vibrant life.


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